On May 22, 1783, Jacob Shellman Baer, who practiced medicine in Frederick and Middletown for 57 years, was born in Frederick County.
On May 22, 1832, the installation of the first oil street lamps on Frederick streets was completed.
On May 22, 1900, a contract was awarded to Harry W. Bowers to build a new Female High School on East Church Street in Frederick. This building was used for many years as the headquarters of The Frederick County Board of Education.
On May 22, 1903, Zion Reformed Church at Charlesville, Frederick County, was struck by lightning and destroyed by the ensuing fire.
On May 22, 1914, the Civic Club of Frederick established the Frederick County Free Library and opened it in the YMCA building at the corner of West Church and North Court streets.
On May 22, 1960, a herd of intoxicated heifers led Frederick County Sheriff's deputies to a still off Fingerboard Road. Thomas Dawkins and Robert Winston were arrested.
On May 22, 1984, Dr. George Joseph Snowball, who practiced dentistry in Frederick for 57 years (1913-1970), and who retired at age 92, died at age 105.